TABLE 2.

Ongoing human clinical trials.

Clinical trial identifier	Status	Title	Study design	Drug	Intervention arms	Primary outcome measure
NCT03241732	Recruiting	PET-MRI and the effect of N-acetyl cysteine and anti-inflammatory diet in TBI	Non-randomized, crossover	NAC	1. Dietary arm 2. IV/PO arm 3. Control arm	FDG-PET to measure inflammation and oxidative damage in the brain
NCT04291066	Active, not recruiting	Prospective analysis of the use of N-acetyl cysteine and vitamins in the treatment of TBI in geriatric patients	Randomized, prospective	NAC and oral multivitamins	1. Experimental 2. Non-treatment (routine care)	Determine improvement in somatic, cognitive, and emotional post-concussion symptoms

NAC, N-acetyl cysteine; TBI, traumatic brain injury; IV, intravenous; PO, per os; FDG-PET, fluorodeoxyglucose-positron emission tomography.