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Modeling of hinge-hinge interactions. The extracellular part of the CD28 receptor and CARs engineered with a CD28, IgG4, or CD8 HD were modeled as CD28-CAR heterodimers (top) or as CAR-CAR homodimers (bottom). Black arrows point to locations of possible disulfide bonds in the HD. Disulfide bonds are depicted in red. The start of the transmembrane domain is represented by gray circles.
