TABLE 3.
Statistical comparison of outcome characteristics between uninterrupted and interrupted direct oral anticoagulation in patients undergoing catheter ablation of atrial fibrillation
| UA (e/n) | IA (e/n) | Log OR (95% CI) | P value | Z value | I 2 (%) | Tau2 | Predicted OR (95% CI) | |
|---|---|---|---|---|---|---|---|---|
| Primary outcomes | ||||||||
| MACCVE | 7/840 | 12/938 | ‒0.40 (‒1.33 to 0.53) | .40 | ‒0.85 | 0 | 0 | 0.67 (0.26 to 1.70) |
| Total bleeding | 54/735 | 58/710 | ‒0.12 (‒0.51 to 0.27) | .55 | ‒0.60 | 0 | 0 | 0.89 (0.60 to 1.31) |
| Silent cerebral events | 95/617 | 169/683 | ‒0.90 (‒1.59 to ‒0.22) | <.01 | ‒2.59 | 33 | 73.15 | 0.41 (0.20 to 0.80) |
| Secondary outcome | ||||||||
| Stroke/TIA | 3/840 | 4/938 | ‒0.02 (‒1.46 to 1.41) | .98 | ‒0.03 | 0 | 0 | 0.98 (0.23 to 4.11) |
| Major bleeding | 4/735 | 8/710 | ‒0.65 (‒1.80 to 0.51) | .27 | ‒1.10 | 0 | 0 | 0.52 (0.17 to 1.66) |
| Minor bleeding | 55/840 | 66/938 | ‒0.09 (‒0.47 to 0.29) | .63 | ‒0.49 | 0 | 0 | 0.91 (0.62 to 1.33) |
| Total pericardial effusion | 5/735 | 6/710 | ‒0.27 (‒1.47 to 0.94) | .67 | ‒0.43 | 0 | 0 | 0.77 (0.23 to 2.56) |
| Cardiac tamponade | 2/735 | 3/710 | ‒0.36 (‒2.34 to 1.63) | .73 | ‒0.35 | 19 | 0.59 | 0.70 (0.10 to 5.11) |
| Total puncture complications | 24/735 | 25/710 | ‒0.12 (‒0.69 to 0.44) | .68 | ‒0.42 | 0 | 0 | 0.89 (0.50 to 1.56) |
Abbreviations: IA, interrupted anticoagulation group; MACCVE, major adverse cerebro‐cardiovascular events; OR, odds ratio; TIA, transient ischemic attack; UA, uninterrupted anticoagulation group.