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. Author manuscript; available in PMC: 2021 Apr 6.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2020 Oct 7;183(8):464–474. doi: 10.1002/ajmg.b.32824

FIGURE 3.

FIGURE 3

GABRA2 methylation levels are illustrated for multiple iPSC clones (4–5) generated from seven different fibroblast lines. Clones derived from an individual donor fibroblast line were frequently discordant for level of methylation (i.e., low, intermediate, or high) in the GABRA2 promoter-proximal CpG island, suggesting a strong clone-specific methylation effect at the GABRA2 locus as a result of reprogramming. Donor genotype at rs279858: ○ = T/T; □ = C/T; Δ = C/C