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. 2021 Apr 6;22:99. doi: 10.1186/s12931-021-01698-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Enriched gene expression pattern of AV treatment may prevent the SARS-CoV2 infection-induced transcriptional changes a The volcano plot represents the variable expression status of genes upon AV-D2 and AV-D4 treatment in mice's lungs compared to the vehicle group. Red and green coloured dots represent up and down-regulated genes (FC > |2|, P-value < 0.05). b Heatmap represents the top 50 most variable genes in the AV-D4 group and their expression status in Vehicle, AV-D2, and AV-D4 group. c Enriched pathways and biological process in up-regulated and down-regulated genes after AV treatment compared to vehicle mice group