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. 2021 Feb 6;62:100031. doi: 10.1194/jlr.RA120000856

Fig. 2.

Fig. 2

PI comparisons of whole liver from WT and Mboat7 LSKO mice (n = 6 per group). A: PI composition (left) and concentrations of total PI and PI 38:4(18:0, 20:4) (right) from the whole-liver lysates of WT and Mboat7 LSKO mice. The percentage of PI 38:4(18:0, 20:4) in total PIs was highlighted in blue color. Hepatic concentrations of PIs that decreased in Mboat7 LSKO mice with 20-carbon fatty acids PI 36:3(16:0, 20:3), PI 38:2(18:0, 20:2), and PI 38:3(18:0, 20:3) (B); PIs containing saturated and monounsaturated fatty acids PI 34:1(16:0, 18:1), PI 36:2(18:1, 18:1), and PI 36:1(18:0, 18:1) (C); and PIs containing PUFAS PI 40:7(18:1, 22:6), PI 36:4(18:1, 18:3), and PI 40:6(18:0, 22:5) (D) were compared between WT and Mboat7 LSKO mice. E: LPIAT activity was examined in liver membrane fraction from WT and Mboat7 LSKO mice (n = 3 per group). The production rates of 16:0-, 18:0-, 18:1-, 18:2-, 18:3-, and 20:4/17:1-PI were compared between WT and Mboat7 LSKO mice. Data are presented as mean ± SD. The asterisks denote the level of statistical significance (Student's t-test) between WT and Mboat7 LSKO mice: ∗P < 0.05, ∗∗P < 0.005, ∗∗∗P < 0.001, ∗∗∗∗P > 0.0005. LPIAT, lysophosphatidylinositol acyltransferase; Mboat7 LSKO, Mboat7 liver-specific KO mice; PI, phosphatidylinositol.