Fig. 3.

Plasma TG and total cholesterol concentrations and in vivo VLDL secretion in WT and Mboat7 LSKO mice. A: Plasma TG and cholesterol levels of WT and Mboat7 LSKO mice (n = 5 per group). B: Plasma TG secretion rate during a detergent block of lipolysis was calculated for each mouse from the linear regression analysis of the time versus TG concentration. C: Six male mice of each genotype were fasted for 4 h before the study. Each mouse was injected intravenously with a 10% Triton-saline solution at 500 mg/kg. Plasma TG accumulation of each mouse at 0, 0.5, 1, 1.5, 2, 2.5, and 3 h after the Triton injection were measured. Mboat7 LSKO, Mboat7 liver-specific KO mice; TG, triglyceride.