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. 2021 Apr 6;12:226. doi: 10.1186/s13287-021-02257-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Wound healing in a diabetic rat excisional wound model and histology of wound beds posttreatment. a Representative images of the wounds show that compared to PBS, PRP, and ADSCs, treatment with ADSC+PRP accelerated wound healing, and full epithelialization was observed by day 10. Scale bar = 1 cm. b The wound closure percentage was evaluated postwounding. The ADSC+PRP group exhibited significantly accelerated wound healing compared to that exhibited by the other groups. Values were expressed as mean ± SEM (n = 12 animals per group, 24 wounds total per group). Statistics were performed using one-way ANOVA and showed statistically significant differences between groups, all six combinations of groups (PBS and PRP, PBS and ADSCs, PBS and ADSC+PRP, PRP and ADSCs, PRP and ADSCs+PRP, and ADSCs and ADSCs+PRP) were statistically significant with *p < 0.05 or better, as evaluated by Tukey post hoc test. c Hematoxylin and eosin staining on day 14 postwounding showed a thicker epidermis and increased appendages in the dermis of the ADSC+PRP group compared with the other groups. Scale bars = 50 μm. d Collagen deposition in the dermis was visualized with Masson’s trichrome staining and microscopy. The analysis generally demonstrated that compared to PBS, PRP, and ADSCs, treatment with ADSC+PRP promoted epithelialization. Scale bars = 50 μm (significance was set to *p < 0.05, **p < 0.01, and ***p < 0.001)