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. 2021 Apr 6:1–15. doi: 10.1080/07420528.2021.1903027

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This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 1. — The crystal structure of SARS-CoV-2 M^pro in complex with SRT2183. (a) A cartoon presentation of M^pro-inhibitor complex. (b) Surface presentation of M^pro. SRT2183 is presented in green color sticks. (c) A zoomed view of substrate-binding pocket representing the key amino acid residues forming interactions with inhibitor molecule. (d) Surface presentation of conserved substrate-binding pocket of SARS-CoV-2 M^pro