Table 3.

Interacting amino acid residues of target protein SARS-CoV-2 M^pro with five proposed circadian clock-modulating small molecules as its potent inhibitors

S.No.	Small molecules	Target protein	Integrating amino acid residues
1.	SRT2183	SARS-CoV-2 Mpro	GLN110, PRO252, ILE249, VAL297, PRO293, VAL202, PHE294, LEU253, THR292, ASN151, PHE8, THR111, ASN203, HIS246.
2.	Neoruscogenin		LEU287, LYS137, LEU272, LEU286, GLY275, LEU271, TYR239, GLU288, THR199, ASP289, ARG131.
3.	SR10067		ASN151, GLN110, PHE294, ASP153, VAL104, ILE249, PRO293, ILE152, PHE8, TYR154, SER158, LYS102, THR292, THR111.
4.	SRT1720		GLN110, VAL202, PRO293, ILE249, PHE294, PRO252, HIS246, ASN203, THR292, GLY109, PHE8, ASN151, ASP295, THR111, VAL297.
5.	CX-4945		THR111, ASN151, ASP295, PHE294, PRO293, ILE249, THR292, PHE112, PHE8, ILE152, ASP153, TYR154, GLN110.