Fig. 2.
Dependence of NS9283 potentiation on ACh concentration. a–i Single-channel currents from (α4)3(β2)2 AChRs were recorded in the presence of the indicated concentrations of ACh, without or with 30 μM NS9283 (holding potential − 70 mV, Gaussian filter 4 kHz). To the right of each trace are histograms of un-potentiated and potentiated channel openings, respectively, determined as described in the text and Fig. 1, fitted by the sum of three exponentials. Exponential components of potentiated channel openings are shaded. Percentage of channel openings that are potentiated is indicated by the shaded portion of the bar