Table 3 -. Top Most significant enriched gene ontology (GO) terms.
| Category | Id | Term | Count | Genes | P-valuea |
|---|---|---|---|---|---|
| Upregulated | |||||
| BP | GO.0098754 | Detoxification | 5 | GSR|SOD1|GPX4|NFE2L2|GPX1 | 5.92E-08 |
| BP | GO.0006979 | Response to oxidative stress | 6 | GSR|SOD1|GPX4|NFE2L2|GPX1|SELENOP | 1.50E-07 |
| BP | GO.0097237 | Cellular response to toxic substance | 5 | GSR|SOD1|GPX4|NFE2L2|GPX1 | 6.26E-07 |
| BP | GO.0098869 | Cellular oxidant detoxification | 4 | GSR|SOD1|GPX4|GPX1 | 3.10E-06 |
| BP | GO.1902175 | Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 3 | SOD1|NFE2L2|GPX1 | 2.18E-05 |
| BP | GO.0034599 | Cellular response to oxidative stress | 4 | GSR|SOD1|NFE2L2|GPX1 | 6.32E-05 |
| BP | GO.0006749 | Glutathione metabolic process | 3 | GSR|SOD1|GPX1 | 6.95E-05 |
| BP | GO.0045454 | Cell redox homeostasis | 3 | GSR|NFE2L2|GPX1 | 1.20E-04 |
| BP | GO.0042542 | Response to hydrogen peroxide | 3 | SOD1|NFE2L2|GPX1 | 4.20E-04 |
| BP | GO.0019372 | Lipoxygenase pathway | 2 | GPX4|GPX1 | 7.50E-04 |
| MF | GO.0016209 | Antioxidant activity | 4 | GSR|SOD1|GPX4|GPX1 | 7.40E-07 |
| MF | GO.0004602 | Glutathione peroxidase activity | 2 | GPX4|GPX1 | 8.10E-04 |
| MF | GO.0016491 | Oxidoreductase activity | 4 | GSR|SOD1|GPX4|GPX1 | 0.0014 |
| CC | GO.0070013 | Intracellular organelle lumen | 7 | GSR|SOD1|SEP15|GPX4|NFE2L2|GPX1|SEPP1 | 0.0067 |
| CC | GO.0005759 | Mitochondrial matrix | 3 | GSR|SOD1|GPX1 | 0.0082 |
| CC | GO.0005739 | Mitochondrion | 4 | GSR|SOD1|GPX4|GPX1 | 0.0163 |
| Downregulated | |||||
| BP | GO.0000302 | Response to reactive oxygen species | 2 | CAT|SOD2 | 0.0057 |
| BP | GO.0034599 | Cellular response to oxidative stress | 2 | CAT|SOD2 | 0.0057 |
| BP | GO.0051289 | Protein homotetramerization | 2 | CAT|SOD2 | 0.0057 |
| BP | GO.0072593 | Reactive oxygen species metabolic process | 2 | CAT|SOD2 | 0.0057 |
| BP | GO.0098869 | Cellular oxidant detoxification | 2 | CAT|SOD2 | 0.0057 |
| BP | GO.0007568 | Aging | 2 | CAT|SOD2 | 0.006 |
| BP | GO.0010035 | Response to inorganic substance | 2 | CAT|SOD2 | 0.0157 |
| BP | GO.0043066 | Negative regulation of apoptotic process | 2 | CAT|SOD2 | 0.0419 |
| BP | GO.0055114 | Oxidation-reduction process | 2 | CAT|SOD2 | 0.043 |
| MF | GO.0016209 | Antioxidant activity | 2 | CAT|SOD2 | 5.8E-4 |
| MF | GO.0016491 | Oxidoreductase activity | 2 | CAT|SOD2 | 0.0229 |
GO, gene ontology; BP, biological process; MF, molecular function; CC, cellular component; a Corrected p-value