Table 4 -. Top Most significant enriched pathways.

Category	Id	Term	Count	Genes	P-valuea
Upregulated
K	hsa00480	Glutathione metabolism	3	GSR|GPX4|GPX1	8.46E-06
R	HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	2	GPX4|GPX1	7.05E-05
R	HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	2	GPX4|GPX1	7.05E-05
R	HSA-2142688	Synthesis of 5-eicosatetraenoic acids	2	GPX4|GPX1	7.05E-05
R	HSA-3299685	Detoxification of Reactive Oxygen Species	2	SOD1|GPX1	4.20E-04
K	hsa05014	Amyotrophic lateral sclerosis (ALS)	2	SOD1|GPX1	9.40E-04
K	hsa04918	Thyroid hormone synthesis	2	GSR|GPX1	0.0013
R	HSA-114608	Platelet degranulation	2	SOD1|SEPP1	0.0033
K	hsa05016	Huntington’s disease	2	SOD1|GPX1	0.0065
Downregulated
R	HSA-3299685	Detoxification of Reactive Oxygen Species	2	CAT|SOD2	6.61E-5
K	hsa04146	Peroxisome	2	CAT|SOD2	9.18E-5
K	hsa04211	Longevity regulating pathway	2	CAT|SOD2	9.18E-5
K	hsa04068	FoxO signaling pathway	2	CAT|SOD2	1.0E-4
R	HSA-2262752	Cellular responses to stress	2	CAT|SOD2	0.003
R	HSA-8953897	Cellular responses to external stimuli	2	CAT|SOD2	0.003
R	HSA-168256	Immune System	2	CAT|SOD2	0.046

K, KEGG Pathways; R, REACTOME Pathways; a Corrected p-value