Table 1.
Results of univariate and multivariate analyses of the clinicopathological factors for recurrence-free survival rates
| Factors | Univariate analysis | Multivariate analysis | |
|---|---|---|---|
| N | 3 years (%) | P-value | |
| Gender | |||
| Male | 63 | 32.6 | - |
| Female | 25 | 40.9 | 0.361 |
| BMI | |||
| < 23 | 39 | 35.9 | - |
| ≥ 23 | 49 | 34.4 | 0.910 |
| Location | |||
| Colon | 47 | 34.8 | - |
| Rectum | 41 | 34.6 | 0.853 |
| Location | |||
| Right side | 12 | 15.0 | |
| Left side | 67 | 37.2 | |
| Transverse | 9 | 44.4 | 0.125 |
| Timing of liver metastasis | |||
| Metachronous | 46 | 39.4 | |
| Synchronous | 42 | 30.7 | 0.190 |
| Synchronous lung metastasis | |||
| Absent | 83 | 35.0 | |
| Present | 5 | 40.0 | 0.590 |
| Number of tumors | |||
| 1 | 46 | 49.0 | |
| 2–4 | 28 | 20.8 | |
| ≥ 5 | 14 | 19.2 | 0.030 |
| Largest tumor diameter | |||
| < 5 cm | 73 | 34.1 | |
| ≥ 5 cm | 15 | 37.0 | 0.999 |
| CEA level (before hepatectomy) | |||
| < 5 ng/ml | 35 | 27.9 | |
| ≥ 5 ng/mL | 52 | 38.5 | 0.438 |
| CA19-9 level (before hepatectomy) | |||
| < 38 U/mL | 63 | 29.6 | |
| ≥ 38 U/mL | 24 | 49.7 | 0.759 |
| Stage (primary tumor) | |||
| I–III | 42 | 43.7 | |
| IV | 46 | 27.3 | 0.041 |
| Liver metastasis classification | |||
| H1 | 55 | 47.6 | |
| H2–3 | 28 | 19.9 | 0.013 |
| Prognosis grade classification | |||
| Grade A | 50 | 48.7 | |
| Grade B, C | 32 | 17.3 | 0.005 |
| Primary tumor differentiation | |||
| Well-differentiated | 46 | 35.5 | |
| Others | 42 | 34.5 | 0.775 |
| lympatic invasion (primary tumor) | |||
| Negative | 29 | 41.5 | |
| Positive | 59 | 31.6 | 0.161 |
| venous invasion (primary tumor) | |||
| Negative | 59 | 43.1 | |
| Positive | 29 | 19.9 | 0.021 |
| N | |||
| Negative | 27 | 42.3 | |
| Positive | 61 | 31.3 | 0.057 |
| Beppu’s nomogram score | |||
| < 6 | 34 | 49.2 | |
| ≥ 6 | 54 | 26.5 | 0.027 1.994 (1.083–3.672) 0.027 |
| Chemotherapy before hepatectomy | |||
| Absent | 30 | 46.8 | |
| Present | 58 | 29.4 | 0.029 1.962 (1.092–3.524) 0.024 |
| Operative procedure | |||
| Laparoscopic hepatectomy | 26 | 36.1 | |
| Open hepatectomy | 62 | 34.3 | 0.493 |
BMI body mass index, mGPS modified Glasgow prognostic score, NLR neutorophil lymphocyte ratio, PNI prognostic nutrition index, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9