Fig. 7.

SNHG16 was directly targeted by miR-1285-3p. (A) The miR-1285-3p expression in five OS cell lines and a normal osteoblast cells. (B)The relative expression of miR-1285-3p mimics, inhibitors and negative control were detected in MNNG cells. (C) (D) Cell proliferation is suppressed by miR-1285-3p mimics. (E) Upregulated miR-1285-3p reduced migration and invasion of MNNG cells. (F) (G) Increasing miR-1285-3p in the MNNG cells promoted the rates of G2/M phase relative to the NC group, and enhancing expression of miR-1285-3p resulted in increased apoptosis