Table 5.
Ontology analysis by gene-term enrichment, considering the Danio rerio interacting-validated genes targets of the DE miRNAs, showing the genes and the ontology categories of signaling pathways. alas2–5-aminolevulinate synthase 2; lmo2 - LIM Domain Only 2; jun - AP-1 Transcription factor Subunit; meis1 - Meis Homeobox 1
| Signaling Pathways | Genes | |
|---|---|---|
| Biological Process | oxygen homeostasis (GO:0032364) | alas2 |
| gas homeostasis (GO:0033483) | alas2 | |
| cellular response to thyroid hormone stimulus (GO:0097067) | lmo2 | |
| negative regulation of transcription from RNA polymerase II promoter in response to stress (GO:0097201) | jun | |
| regulation of DNA-templated transcription, initiation (GO:2000142) | jun | |
| mRNA transcription from RNA polymerase II promoter (GO:0042789) | lmo2 | |
| negative regulation of hemopoiesis (GO:1903707) | meis1 | |
| negative regulation by host of viral transcription (GO:0043922) | jun | |
| mRNA transcription (GO:0009299) | lmo2 | |
| positive regulation of vascular smooth muscle cell proliferation (GO:1904707) | jun | |
| Cellular Component | nuclear euchromatin (GO:0005719) | jun |
| euchromatin (GO:0000791) | jun | |
| nuclear chromosome (GO:0000228) | jun | |
| chromosome (GO:0005694) | jun | |
| Molecular Function | transcriptional repressor activity, RNA polymerase II activating transcription factor binding (GO:0098811) | jun; lmo2 |
| activating transcription factor binding (GO:0033613) | jun; lmo2 | |
| transcriptional activator activity, RNA polymerase II transcription factor binding (GO:0001190) | jun; lmo2 | |
| cAMP response element binding (GO:0035497) | jun | |
| RNA polymerase II activating transcription factor binding (GO:0001102) | jun; lmo2 | |
| glycine binding (GO:0016594) | alas2 | |
| R-SMAD binding (GO:0070412) | jun | |
| RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) | jun |