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. 2020 Aug 26;31(3):231–242. doi: 10.1093/glycob/cwaa082

Fig. 10.

Fig. 10

Human Siglec-11 can be secreted and bind cell surface polySia at a distance. Siglec-11 has been considered to exist as a membrane protein on cell surface and interact with oligo/polySia on cell surface. Here, we propose that Siglec-11 can be proteolytically cleaved from cell surface and the ECD exist as a shed soluble protein. Moreover, the microglial form hSiglec-11(4D) can be secreted on exosome. Both soluble ECD and full length of hSiglec-11(4D) showed binding to cell surface polySia. Novel pathways of hSiglec-11(4D)-polySia interaction in human brain are proposed.