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. 2020 Dec 24;11(2):jkaa044. doi: 10.1093/g3journal/jkaa044

Table 7.

Goodness of fit of inheritance models with the observed distribution of c.1759T>G genotypes in male population (n = 43)

TT GT GG
Observed distribution
1 42 0
Inheritance modelsa Expected distribution P b
Autosomal locusc 11.3 21.4 10.3 2.97 × 10−7
Lethal GG homozygoted 14.9 28.1 0 2.83 × 10−4
Male determination by Ge 0 43 0 0.99
a

H0—there is no difference between observed and expected distributions based on the inheritance model with allele frequencies p(T) = 0.512 and q(G) = 0.488.

b

Fisher exact test: 2 × 3 tool (http://vassarstats.net/fisher2x3.html).

c

Hardy–Weinberg equilibrium: p2, 2pq, q2.

d

Elimination of q2: p2/(1 − q2), 2pq/(1 − q2), 0.

e

Elimination of q2 and p2: 0, 1, 0.