Table 7.
Goodness of fit of inheritance models with the observed distribution of c.1759T>G genotypes in male population (n = 43)
TT | GT | GG | ||
---|---|---|---|---|
Observed distribution | ||||
1 | 42 | 0 | ||
Inheritance modelsa | Expected distribution | P b | ||
Autosomal locusc | 11.3 | 21.4 | 10.3 | 2.97 × 10−7 |
Lethal GG homozygoted | 14.9 | 28.1 | 0 | 2.83 × 10−4 |
Male determination by Ge | 0 | 43 | 0 | 0.99 |
H0—there is no difference between observed and expected distributions based on the inheritance model with allele frequencies p(T) = 0.512 and q(G) = 0.488.
Fisher exact test: 2 × 3 tool (http://vassarstats.net/fisher2x3.html).
Hardy–Weinberg equilibrium: p2, 2pq, q2.
Elimination of q2: p2/(1 − q2), 2pq/(1 − q2), 0.
Elimination of q2 and p2: 0, 1, 0.