Table 1.
Change in clinical and histological variables between first and second biopsy
| Clinical variable | Biopsy 1 | Biopsy 2 | P |
|---|---|---|---|
| Hypertension (%) | 15 (24.2%) | 21 (33.9%) | 0.180 |
| Serum creatinine (median; IQR) mg/dl | 0.9 (0.7-2.01) | 1.32 (0.8-2.1) | 0.596 |
| Serum creatinine >3 mg/dl (%) | 10 (16.1%) | 9 (14.5%) | 1.00 |
| Serum albumin (median; IQR) g/dl | 2.6 (2.1-3.0) | 2.82 (2.1-3.3) | 0.047 |
| Hypoalbuminemia <3 g/dl (%) | 45 (72.6%) | 33 (53.2%) | 0.038 |
| 24 h urine protein (median; IQR) g/day | 2.8 (1.95-4.2) | 2.8 (1.88-4.85) | 0.736 |
| 24 h urine protein >4 g/day (%) | 19 (30.6%) | 19 (30.6%) | 1.00 |
| Low C3 (%) | 51 (82.3% ) | 33 (53.2%) | <0.001 |
| Low C4 (%) | 34 (54.8%) | 14 (22.6%) | <0.001 |
| Hemoglobin (median; IQR) g/dl | 9.2 (8.2-10.2) | 9.65 (8.87-11) | 0.014 |
| Histological variable | |||
| Glomerulosclerosis (%) | 15 (24.2%) | 29 (46.8%) | 0.018 |
| Endocapillary proliferation (%) | 50 (80.6%) | 40 (64.5%) | 0.013 |
| Glomerular basement membrane thickening (%) | 22 (35.5%) | 40 (64.5%) | <0.001 |
| Wireloop lesion (%) | 14 (22.6%) | 19 (30.6%) | 0.359 |
| Crescents >50% of glomeruli (%) | 10 (16.1%) | 10 (16.1%) | 1.00 |
| Fibrinoid necrosis (%) | 9 (14.5%) | 3 (4.8%) | 0.070 |
| Glomerular leucocyte infiltration (%) | 4 (6.5%) | 4 (6.5%) | 1.00 |
| Interstitial inflammation (%) | 38 (61.3%) | 42 (67.7%) | 0.571 |
| Fibrous crescent (%) | 8 (12.9%) | 11 (17.7%) | 0.581 |
| IFTA >30% of cortex (%) | 2 (3.2%) | 10 (16.1%) | 0.021 |
| ATN (%) | 15 (24.2%) | 21 (33.9%) | 0.307 |
| Arteriosclerosis (%) | 14 (22.6%) | 23 (37.1%) | 0.078 |
| TMA (vascular±glomerular) (%) | 6 (9.7%) | 10 (16.1%) | 0.388 |
| IgG intensity ≥3+ (%) | 43 (69.4%) | 39 (62.9%) | 0.164 |
| C1q intensity ≥3+ (%) | 24 (38.7%) | 20 (32.5%) | 0.571 |
| C3 intensity ≥3+ (%) | 34 (54.8%) | 24 (38.7%) | 0.089 |