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. 2021 Mar 23;11:648052. doi: 10.3389/fonc.2021.648052

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Copyright © 2021 Shi, Li, Zhang, Deng, Liu, Du, Li, Ji, Guo, Liu, Hu, Liu and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHC inhibits the migration and invasion of melanoma cells. (A) Wound closure proportion of A375 and MV3 cells under the treatment of 100 μM DHC. Scale bar, 100 μm. (B, C) Migration and invasion transwell assays were performed in A375 and MV3 cells treated with 100 μM DHC. Scale bar, 100 μm. (D, F) The protein and mRNA levels of β-catenin, MMP2, and MMP7 in A375 and MV3 cells treated with 0, 50, 100, and 200 μM DHC for 48 h. (E, G) The protein and mRNA levels of β-catenin, MMP2, and MMP7 in A375 and MV3 cells treated with 100 μM DHC for 0, 12, 24, and 48 h. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.