Table 2.
Polymorphisms associated with modulation of pain perception
| Gene | Polymorphism; alleles (risk allele) | Pain-related manifestation | Reference |
| ABCC4 | rs4584690; T>A,C,G (T) | Acute post-radiotherapy pain in breast cancer | [15] |
| Intergenic | rs11786084; G>A (G) | Multisite chronic pain | [16] |
| Intergenic | rs1443914; T>C (T) | Multisite chronic pain | [16] |
| ANAPC4 | rs34811474; G>A,T (G) | Multisite chronic pain | [16] |
| ASTN2 | rs6478241; A>G,T (A) | Multisite chronic pain | [16] |
| BBX | rs28428925; G>A (G) | Multisite chronic pain | [16] |
| ILRUN | rs6907508; A/G (A) | Multisite chronic pain | [16] |
| GSDMC | rs7833174; T>C,G (T) | Chronic back pain | [17] |
| Intergenic | rs13361160; T>C (C) | Pain | [18] |
| CEP120 | rs17474406; G>A (G) | Multisite chronic pain | [16] |
| Intergenic | rs2006281; C>G,T (C) | Multisite chronic pain | [16] |
| CTNNA2 | rs4852567; A>G,T (A) | Multisite chronic pain | [16] |
| DCC | rs4384683; G>A,C,T (G) | Chronic back pain | [17] |
| rs62098013; G>A (G) | Multisite chronic pain | [16] | |
| DIS3L2 | rs1453867; C>G,T (C) | Chronic back pain | [17] |
| Intergenic | rs17428041; T>C (T) | Neuropathic pain in type 2 diabetes | [19] |
| DYNC1I1 | rs6966540; T>A,C,G (T) | Multisite chronic pain | [16] |
| Intergenic | rs73633565; A>G (G) | Acute post-radiotherapy pain in breast cancer | [20] |
| FAF1 | rs10888692; C>G (C) | Multisite chronic pain | [16] |
| Intergenic | rs12596162; C>A,T (A) | Possible neuropathic pain in post total joint replacement surgery for osteoarthritis | [21] |
| FOXP2 | rs12537376; A>G,T (A) | Multisite chronic pain | [16] |
| GABRB2 | rs1946247; T>G (T) | Multisite chronic pain | [16] |
| GDF5 | rs143384; G>A (A) | Knee pain | [22] |
| rs6120946; A>T (A) | Knee pain | [22] | |
| GPD2 | rs298235; A>C,G,T (A) | Possible neuropathic pain in post total joint replacement surgery for osteoarthritis | [21] |
| Intergenic | rs6986153; G>A,C,T (G) | Neuropathic pain in type 2 diabetes | [23] |
| KCND3 | rs197422; C>A,G (C) | Multisite chronic pain | [16] |
| KNDC1 | rs12765185; T>A (T) | Multisite chronic pain | [16] |
| Intergenic | rs59898460; T>C,G (T) | Multisite chronic pain | [16] |
| Intergenic | rs919642; A>T (A) | Knee pain | [22] |
| Intergenic | rs2808772; A>G,T (A) | Knee pain | [22] |
| MAML3 | rs13136239; G>A,T (G) | Multisite chronic pain | [16] |
| MLLT10 | rs2183271; T>C (T) | Multisite chronic pain | [16] |
| MLN | rs11751591; G>A,T (G) | Multisite chronic pain | [16] |
| Intergenic | rs285026; G>A,C,T (G) | Multisite chronic pain | [16] |
| NMT1 | rs11871043; T>C (T) | Multisite chronic pain | [16] |
| Intergenic | rs12464483; G>A,C (A) | Pre-treatment pain in head and neck squamous cell carcinoma | [24] |
| Intergenic | rs1834077; C>A,T (A) | Pre-treatment pain in head and neck squamous cell carcinoma | [24] |
| NUMB | rs12435797; G>A,C,T (G) | Multisite chronic pain | [16] |
| PRC1 | rs2386584; T>A,C,G (T) | Multisite chronic pain | [16] |
| PRKCA | rs887797; G>A,T (A) | Possible neuropathic pain in post total joint replacement surgery for osteoarthritis | [21] |
| RFFL | rs16970540; C>T (T) | Acute post-radiotherapy pain in breast cancer | [20] |
| RNF123, AMIGO3 | rs7628207; T>A,C,G (T) | Multisite chronic pain | [16] |
| RORA | rs4775319; G>A (G) | Neuropathic pain in head and neck cancer | [25] |
| Intergenic | rs11615866; C>T (T) | Neuropathic pain in type 2 diabetes | [19] |
| Intergenic | rs12071912; C>G,T (C) | Multisite chronic pain | [16] |
| Intergenic | rs6869446; T<A,C,G (T) | Multisite chronic pain | [16] |
| Intergenic | rs1976423; A>C (A) | Multisite chronic pain | [16] |
| SDK1 | rs10259354; G>A,C (G) | Multisite chronic pain | [16] |
| SLC24A3 | rs2424248; G>A,T (G) | Multisite chronic pain | [16] |
| SLC39A8 | rs13135092; A>G (A) | Multisite chronic pain | [16] |
| Intergenic | rs11079993; G>A,T (G) | Multisite chronic pain | [16] |
| SNX8 | rs10950641; G>A (A) | Neuropathic pain in head and neck cancer | [25] |
| SORCS3 | rs11599236; T>A,C,G (T) | Multisite chronic pain | [16] |
| SOX5 | rs12310519; C>T (T) | Chronic back pain | [17] |
| SOX6 | rs61883178; C>A (C) | Multisite chronic pain | [16] |
| SP4 | rs7798894; A>C,G,T (A) | Multisite chronic pain | [16] |
| STAG1 | rs6770476; C>T (C) | Multisite chronic pain | [16] |
| UTRN | rs6926377; A>C (A) | Multisite chronic pain | [16] |
| Intergenic | rs10992729; C>G,T (C) | Multisite chronic pain | [16] |
| ZSCAN20 | rs35260355; C>A,G,T (T) | Neuropathic pain in type 2 diabetes | [23] |
| rs71647933; A>G,T (G) | Neuropathic pain in type 2 diabetes | [23] | |
| SCN9A | rs6746030; A>C,G (A) | Increased pain in patients with osteoarthritis, sciatica and phantom limb syndrome | [8] |
| CACNA2D3 | rs6777055; A>C (C) | Reduced acute thermal pain and diminished chronic pain after lumbar discectomy | [9] |
| KCNS1 | rs734784; T>C (C) | Increased acute pain in patients with neuropathic pain after radiculopathy or amputation | [10] |
| CACNG2 | rs4820242; G>A,C,T (A) | Increased susceptibility to chronic pain after nerve injury in mastectomy patients. | [11] |
| rs2284015; C>G (G) | [11] | ||
| rs2284017; T>C (C) | [11] | ||
| P2RX7 | rs7958311; G>A,C (A) | Reduction of chronic pain | [12] |
| SCN10A | rs6795970; A>G,T (T) | Anticipated onset of pain | [13] |