FIGURE 9.

Assessment of ASFV-Δ7R virulence in swine. (A) Survival rates of pigs (n = 5 per group) after i.m. inoculation with parental ASFV or ASFV-Δ7R (10 HAD₅₀ per animal). (B) Effects of ASFV-Δ7R on serum levels of IFN-β induced by i.m. inoculation with parental ASFV or ASFV-Δ7R (10 HAD₅₀ per animal) for 6 d (n = 3 per group). (C) Effects of ASFV-Δ7R on IFN-β transcription levels in different tissues (spleen, lung, and lymph) (n = 3 per group). The experiments were similarly performed as in (B). (D) Effects of ASFV-Δ7R or parental ASFV on virus replication in blood and tissues (n = 3 per group). The experiments were similarly performed as in (B). All the experiments were repeated three times with similar results. *p < 0.05, **p < 0.01.