Table 1.

Primary and  secondary TMA forms

Primary TMA	Secondary TMA
TTP Hereditary TTP, acquired/ immune-mediated TTP HUS Acquired HUS: infectious causes (STEC-HUS, S. pneumoniae, Shigella, etc.); antibody against CFH (aHUS) Hereditary HUS: complement gene mutations (aHUS)	Autoimmune diseases Infections Pregnancy SOT HCT Methylmalonic acidaemia Malignancy Medications Malignant hypertension