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. 2021 Mar 31;9:e11133. doi: 10.7717/peerj.11133

Table 3. Functional roles of the 20 hub genes.

No. Gene Full name Function
1 ALB Serum albumin Its main function is the regulation of the colloidal osmotic pressure of blood.
2 ITGAM Integrin alpha-M Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles.
3 MMP9 Matrix metalloproteinase-9 May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration.
4 COL1A1 Collagen alpha-1(I) chain Type I collagen is a member of group I collagen (fibrillar forming collagen).
5 C3 Complement C3 C3 plays a central role in the activation of the complement system.
6 IL4 Interleukin-4 Participates in at least several B-cell activation processes as well as of other cell types.
7 MMP2 72 kDa type IV collagenase Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture.
8 COL1A2 Collagen alpha-2(I) chain Type I collagen is a member of group I collagen (fibrillar forming collagen)
9 SPP1 Osteopontin Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix.
10 CCR5 C-C chemokine receptor type 5 Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
11 NCAM1 Neural cell adhesion molecule 1 This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
12 MPO Myeloperoxidase Part of the host defense system of polymorphonuclear leukocytes.
13 CCL2 C-C motif chemokine 2 Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils.
14 GNG11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.
15 CXCL10 C-X-C motif chemokine 10 Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
16 SOX9 Transcription factor SOX-9 Transcriptional regulator.
17 CCR7 C-C chemokine receptor type 7 Receptor for the MIP-3-beta chemokine.
18 AGT Angiotensinogen Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis
19 RUNX2 Runt-related transcription factor 2 Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis.
20 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor.