Table 1.
TNB-486 has favorable protein biophysical characteristics. Thermal stability of TNB-486 was assessed by determining the melting temperatures (Tonset,Tm1 and Tm2). Further, aggregation propensity was assessed by SEC-UPLC before and after exposure to heat stress. Percent High Molecular Weight (%HMW) species are shown at T = 0 and after 30 days
| Yield (g/L) | Thermal Stability (%HMW): 5⁰C | Thermal Stability (%HMW): 25⁰C | Tonset (⁰C) | Tm1 (⁰C) | Tm2 (⁰C) | ||
|---|---|---|---|---|---|---|---|
| Td0 |
Td30 |
Td0 |
Td30 |
||||
| 3.3 | 0.5 | 0.5 | 0.5 | 0.5 | 57.4 | 67.7 | 76.9 |