Table 4.

The PK parameters of TNB-486 is similar to conventional antibodies. The PK parameters of TNB-486 were evaluated in mice or monkeys and the values are shown below

Parameter	Units	Balb/c mice		Cynomolgus monkey
		1 mg/kg	10 mg/kg	0.1 mg/kg	1 mg/kg	10 mg/kg
Cmax	µg/mL	16.1	183	1.8	16.1	183
Cmax/D	(µg/mL)/(µg/kg)	0.0161	0.018	0.018	0.0161	0.018
t1/2	days	11.4	12.9	12	11.4	12.9
AUCinf	µg/mL*days	168	1599	13.8	168	1599
AUCinf/D	(µg/mL*days)/ (µg/kg)	0.17	0.16	0.14	0.17	0.16
% Extrap	%	41.9	41.4	32.6	41.9	41.4
CL	mL/day/kg	5.99	6.43	7.41	5.99	6.43
Vss	mL/kg	95.6	121	116	95.6	121