µg |
Microgram |
µL |
Microliter |
µM |
Micromolar |
ABC |
Antibody Bound per Cell |
ADC |
Antibody-Drug Conjugate |
ALL |
Acute Lymphoblastic Leukemia |
AUCinf
|
Area Under the Curve from Zero to Infinity |
B-ALL |
B cell Acute Lymphoblastic Leukemia |
BCMA |
B cell Maturation Antigen |
BiTE |
Bispecific T cell Engager |
B-NHL |
B cell Non-Hodgkin’s Lymphoma |
BSA |
Bovine Serum Albumin |
BsAb |
Bispecific Antibody |
CAR-T |
Chimeric Antigen Receptor T cells |
CD |
Cluster of Differentiation |
CDR |
Complementarity-Determining Regions |
CFSE |
Carboxyfluorescein Succinimidyl Ester |
CH1 |
Constant Heavy Chain 1 |
CIEA |
Central Institute for Experimental Animals |
CL |
Clearance |
CLL |
Chronic Lymphoblastic Leukemia |
Cmax
|
Maximum Serum Concentration |
CO2
|
Carbon dioxide |
CRS |
Cytokine Release Syndrome |
CTL |
Cytotoxic T Lymphocyte |
DLBCL |
Diffuse Large B Cell Lymphoma |
dpi |
Days Post Implantation |
DTC |
Dissociated Tumor Cells |
E:T |
Effector:Target |
EC50
|
Half Maximal Effective Concentration |
ELISA |
Enzyme Linked Immunosorbent Assay |
FBS |
Fetal Bovine Serum |
Fc |
Fragment Crystallizable |
FDA |
Food and Drug Administration |
g |
Grams |
IACUC |
Institutional Animal Care and Use Committee |
IFN |
Interferon |
IL |
Interleukin |
IR |
Infrared |
IV |
Intravenous |
KD
|
Equilibrium Dissociation Constant |
kg |
Kilogram |
L |
Liter |
M |
Molarity |
mAb |
Monoclonal Antibody |
mg |
Milligram |
MHC |
Major Histocompatibility Complex |
mL |
Milliliter |
mM |
Millimolar |
MSD |
Meso Scale Discovery |
N |
Normality |
NaCl |
Sodium chloride |
NaN3
|
Sodium Azide |
NC |
Negative Control |
ng |
Nanogram |
NGS |
Next-Generation Sequencing |
nM |
Nanomolar |
nm |
Nanometer |
NOD |
Non-Obese Diabetic |
NOG |
NOD.Cg-Prkdcscid IL2rgtm1Sug/JicTac |
ns |
Not Significant |
PBMC |
Peripheral Blood Mononuclear Cell |
PBS |
Phosphate-Buffered Saline |
PC |
Positive Control |
PE |
Phycoerythrin |
pg |
Picogram |
pi |
Post Implantation |
PK |
Pharmacokinetics |
pM |
Picomolar |
pMHC |
peptide-Major Histocompatibility Complex |
Q5D |
Every 5 Days |
RACE |
Rapid Amplification of cDNA Ends |
RPMI |
Roswell Park Memorial Institute |
SD |
Standard Deviation |
SEC |
Size Exclusion Chromatography |
SEM |
Standard Error Mean |
t1/2
|
Half-Life |
T-BsAb |
T cell-engaging Bispecific Antibody |
TCR |
T cell Receptor |
TDCC |
T cell Dependent Cellular Cytotoxicity |
TGI |
Tumor Growth Inhibition |
Tm
|
Melting Temperature |
TNF |
Tumor Necrosis Factor |
Tonset
|
Onset Temperature |
UPLC |
Ultra Performance Liquid Chromatography |
VH
|
Variable Domain |
VSS
|
Volume of distribution at Steady State |