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. 2021 Apr 4;13(1):1890411. doi: 10.1080/19420862.2021.1890411
µg Microgram
µL Microliter
µM Micromolar
ABC Antibody Bound per Cell
ADC Antibody-Drug Conjugate
ALL Acute Lymphoblastic Leukemia
AUCinf Area Under the Curve from Zero to Infinity
B-ALL B cell Acute Lymphoblastic Leukemia
BCMA B cell Maturation Antigen
BiTE Bispecific T cell Engager
B-NHL B cell Non-Hodgkin’s Lymphoma
BSA Bovine Serum Albumin
BsAb Bispecific Antibody
CAR-T Chimeric Antigen Receptor T cells
CD Cluster of Differentiation
CDR Complementarity-Determining Regions
CFSE Carboxyfluorescein Succinimidyl Ester
CH1 Constant Heavy Chain 1
CIEA Central Institute for Experimental Animals
CL Clearance
CLL Chronic Lymphoblastic Leukemia
Cmax Maximum Serum Concentration
CO2 Carbon dioxide
CRS Cytokine Release Syndrome
CTL Cytotoxic T Lymphocyte
DLBCL Diffuse Large B Cell Lymphoma
dpi Days Post Implantation
DTC Dissociated Tumor Cells
E:T Effector:Target
EC50 Half Maximal Effective Concentration
ELISA Enzyme Linked Immunosorbent Assay
FBS Fetal Bovine Serum
Fc Fragment Crystallizable
FDA Food and Drug Administration
g Grams
IACUC Institutional Animal Care and Use Committee
IFN Interferon
IL Interleukin
IR Infrared
IV Intravenous
KD Equilibrium Dissociation Constant
kg Kilogram
L Liter
M Molarity
mAb Monoclonal Antibody
mg Milligram
MHC Major Histocompatibility Complex
mL Milliliter
mM Millimolar
MSD Meso Scale Discovery
N Normality
NaCl Sodium chloride
NaN3 Sodium Azide
NC Negative Control
ng Nanogram
NGS Next-Generation Sequencing
nM Nanomolar
nm Nanometer
NOD Non-Obese Diabetic
NOG NOD.Cg-Prkdcscid IL2rgtm1Sug/JicTac
ns Not Significant
PBMC Peripheral Blood Mononuclear Cell
PBS Phosphate-Buffered Saline
PC Positive Control
PE Phycoerythrin
pg Picogram
pi Post Implantation
PK Pharmacokinetics
pM Picomolar
pMHC peptide-Major Histocompatibility Complex
Q5D Every 5 Days
RACE Rapid Amplification of cDNA Ends
RPMI Roswell Park Memorial Institute
SD Standard Deviation
SEC Size Exclusion Chromatography
SEM Standard Error Mean
t1/2 Half-Life
T-BsAb T cell-engaging Bispecific Antibody
TCR T cell Receptor
TDCC T cell Dependent Cellular Cytotoxicity
TGI Tumor Growth Inhibition
Tm Melting Temperature
TNF Tumor Necrosis Factor
Tonset Onset Temperature
UPLC Ultra Performance Liquid Chromatography
VH Variable Domain
VSS Volume of distribution at Steady State