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. 2021 Mar 23;11:641174. doi: 10.3389/fcimb.2021.641174

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Copyright © 2021 Brusini, D’Archivio, McDonald and Wickstead

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A stable, co-purifying kinetoplastid outer kinetochore complex. (A) First and second principal components (PC) of integrated spectral intensities (SINQ) for 1564 trypanosome proteins identified in one or more immuno-purifications with YFP-labelled KKIP2-11. A cluster formed by KKIP2-4,6,8-12 defines the extent of a biochemically stable kinetoplastid outer kinetochore (KOK) complex. KKT, KKIP and ribosomal proteins plus near-neighbors from Figure 1 are highlighted. (B) Network analysis of immuno-purification enrichment. To remove likely contaminants, data were processed as log-transformed signal enrichment against non-cross linked KKIP1 immuno-purification. All proteins ≥ 8-fold enriched in more than one experiment are shown. Vertex areas are scaled according to sum log enrichment across all experiments. Edge thickness reflects log enrichment of that specific interaction over threshold. Light gray and dark gray edges represent uni- and bi-directional hits, respectively. Vertices are colored according to the behavior in the legend.