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. Author manuscript; available in PMC: 2021 Apr 6.
Published in final edited form as: J Am Chem Soc. 2020 May 11;142(20):9240–9249. doi: 10.1021/jacs.9b12898

Figure 3.

Figure 3.

Switching properties and cytotoxicity of optojasps. (a) Absorption spectra of cis and trans optojasp-1. (b) Photoswitching reversibility monitored by absorption at 390 nM on pulsed treatment with 390 nm and 450 nm light. (c) Wavelength-dependent cytotoxicity of optojasp-1 determined by MTT assay. (d-f) Photoswitching-dependent cell toxicity profiles for (d) “trans- active” optojasp-3, (e) “cis-active” optojasp-5, (f) jasplakinolide (3). (g) Photophysical and cytotoxicity parameters for optojasps-1–8, see Fig. S1 for details. (h) Wavelength-dependent cytotoxicity of cis-active optojasp-1, related to panel a. All data were obtained with HeLa cells (45 h, pulsed illuminations of 75 ms every 15 s at the specified wavelength or in the dark).