Figure 1.

Generalized additive mixed multivariable model plots showing the association between the age at antiretroviral therapy (ART) (A), human immunodeficiency virus (HIV) RNA viral load (VL) at ART initiation (B), baseline % CD4 (C), and Western blot (WB) score (D) and the HIV reservoir size (HIV copies per million peripheral blood mononuclear cells [PBMCs]). ART combinations at initiation were included as random intercepts. The shaded areas indicate the 95% confidence intervals. Smooth terms are specified showing the effective degrees of freedom (Edf) for each of the variables included in the model. While age at ART initiation and WB score presented a linear association, the effect of VL was only noticeable for individuals with VLs at ART initiation above 6 logs. The effect of baseline CD4% was not maintained above 40%.