Table 1 |.
Prevalence of neuropsychiatric features in patients with SLE
| Feature | Source | Prevalence (%) | Refs |
|---|---|---|---|
| Diffuse psychiatric or neuropsychological syndromes | |||
| Psychosis | CNS | 0.6–11.0 | 1,6,7,206 |
| Anxiety disorder | CNS | 6.4–40.0 | 1,6,206,207 |
| Acute confusional state | CNS | 0.9–7.0 | 1,6,7,206 |
| Mood disorder | CNS | 7.4–65.0 | 1,6,7,206,207 |
| Cognitive impairment | CNS | 6.6–80.0 | 1,6,7,206 |
| Neurological syndromes | |||
| Headache (including migraine and benign intracranial hypertension) | CNS | 12.2–28.3 | 1,6,7,206 |
| Seizure disorders | CNS | 7.0–20.0 | 1,6,7,206 |
| Cerebrovascular disease | CNS | 8.0–15.0 | 1,6,7,206 |
| Movement disorder (chorea) | CNS | 0.9 | 1,6,206,208 |
| Myelopathy | CNS | 0.9–3.9 | 1,6,7 |
| Demyelinating syndrome | CNS | 0.9–2.7 | 1,6,7,206,209,210 |
| Aseptic meningitis | CNS | 0.3–2.7 | 1,6,7,206 |
| Acute inflammatory demyelinating polyradiculopathy (Guillain–Barré syndrome) | PNS | 0.08–1.20 | 1,6,7 |
| Autonomic disorder | PNS | 0.08–1.30 | 1,6,7 |
| Mononeuropathy, single or multiplex | PNS | 0.9–6.9 | 1,6,7 |
| Plexopathy | PNS | NR | 6,7 |
| Polyneuropathy | PNS | 1.5–5.4 | 1,6,7 |
| Myasthenia gravis | PNS | 0.2 | 1,6 |
| Cranial neuropathy | PNS | 1.0 | 1,6,7 |
Some central nervous system (CNS) and most peripheral nervous system (PNS) manifestations are uncommonly studied, with uncertain and/or rare prevalence. NR, not reported; SLE, systemic lupus erythematosus. References cited here discuss the particular presentation and/or its prevalence in SLE.