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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Osteoarthritis Cartilage. 2020 Nov 24;29(2):248–256. doi: 10.1016/j.joca.2020.10.008

Figure 2. Non-invasive joint injury alters NF-κB signaling, sensitivity to evoked mechanical stimuli, and static weight bearing.

Figure 2.

(A and B) Increased luminescent signal was apparent in ipsilateral knees of the INJ group on days 1, 3, 7 and 70 following joint injury, with no changes in contralateral limbs. (C) Mice in the INJ group had persistent increased sensitivity in the hindpaw following injury. (D) Increased NF-κB signaling in joints was associated with reduced withdrawal thresholds in the first week of the study. (E) Mice in the INJ group also had a reduced threshold to noxious mechanical stimuli following joint injury. (F) Static weight bearing was altered up to one week following joint injury. (G) Mice in the INJ group exhibited a trend towards reduced activity, illustrated by animal matched representative traces (H), 2 days post joint injury. CTRL n=5, INJ n=6, *=p<0.05.