Table 3.

Association of transplant-related frailty with mortality in lung transplant recipients

		Baseline
Model	Time-dependent predictor from baseline to 36 months post-transplant	3-months Post-transplant	6-months Post-transplant	12-months Post-transplant
Unadjusted	Frailty (SPPB ≤7)	4.06 (2.06, 7.98)	3.83 (1.91, 7.68)	4.62 (2.27, 9.39)
	1-point worsening in SPPB	1.19 (1.11, 1.29)	1.19 (1.10, 1.29)	1.21 (1.12, 1.31)
Adjusted	Frailty (SPPB ≤7)	2.51 (1.21, 5.23)	2.28 (1.07, 4.88)	3.02 (1.37,6.63)
	1-point worsening in SPPB	1.13 (1.04,1.23)	1.13 (1.03, 1.23)	1.15 (1.05, 1.25)

The Short Physical Performance Battery (SPPB) ranges from 0 to 12. Lower numbers reflect greater frailty. Mortality risk was estimated by Cox’s proportional hazards models with SPPB as a time-dependent predictor, including all SPPB measurements a participant had from baseline to 36 months post-transplant. Results when setting the baseline SPPB at different time points are shown side by side for comparison. All SPPB values before the specified baseline are excluded from the models. The number of participants alive at each of the baseline points is indicated. Models were adjusted for pre-operative age, sex, race, diagnosis, and BMI and FEV1 measured at each visit. Results represent hazard ratio for death with 95% confidence intervals noted in parenthesis.