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. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: Lancet Microbe. 2020 Jun 8;1(2):e84–e92. doi: 10.1016/s2666-5247(20)30011-2

Table 3:

Characteristics of Participants with a Sharp Drop in EBA on Days 1−2

		Sharp drop in EBA for days 1–2
		Not Sharp (N=32)	Sharp (N=17)	Total (N=49)	P-Value

Patients		32 (65%)	17 (35%)	49 (100%)
Regimen	HRZE days 1–2	24 (65%)	13 (35%)	37	1.00^*
	RZE days 1–2	8 (67%)	4 (33%)	12
EBA_0–2 Mean (s.d)	All	−0.09 (0.36)	0.63 (0.22)	0.16 (0.47)	<0.01
	HRZE days 1–2	−0.02 (0.31)	0.61 (0.18)	0.20 (0.41)	<0.01
	RZE days 1–2	−0.28 (0.45)	0.69 (0.34)	0.04 (0.62)	<0.01
EBA_0–14 Mean (s.d)^*	All	0.11 (0.07)	0.19 (0.11)	0.13 (0.09)	0.03
	HRZE days 1–2	0.10 (0.07)	0.20 (0.12)	0.13 (0.10)	0.04
	RZE days 1–2	0.12 (0.08)	0.16 (0.11)	0.13 (0.09)	0.54
Baseline Log₁₀ CFU, Mean (s.d.)	All	5.51 (0.94)	6.20 (1.07)	5.75 (1.03)	0.03
	HRZE days 1–2	5.45 (0.94)	6.24 (1.20)	5.72 (1.09)	0.05
	RZE days 1–2	5.69 (0.96)	6.08 (0.58)	5.82 (0.85)	0.41
Log₁₀ CFU on day 2, Mean (s.d.)	All	5.68 (0.86)	4.93 (1.12)	5.42 (1.02)	0.02
	HREZ days 1–2	5.49 (0.73)	5.01 (1.27)	5.32 (0.97)	0.22
	RZE days 1–2	6.26 (1.02)	4.69 (0.46)	5.74 (1.14)	<0.01
Log₁₀ CFU on day 14, Mean (s.d.)	All	3.90 (0.80)	3.81 (1.22)	3.87 (0.93)	0.80
	HRZE days 1–2	3.92 (0.80)	3.79 (1.32)	3.88 (0.95)	0.79
	RZE days 1–2	3.84 (0.85)	3.83 (1.15)	3.84 (0.91	1.00
Sex	Male	26 (81%)	15 (88%)	41 (84%)	0.70^*
	Female	6 (19%)	2 (12%)	8 (16%)
Age (years), Mean (s.d.)		32.5 (10.7)	30.0 (8.0)	31.6 (9.8)	0.36
BMI (kg/m²), Mean (s.d.)		19.6 (3.3)	19.4 (2.7)	19.6 (3.0)	0.82
HIV Status	HIV negative	30 (94%)	15 (88%)	45 (92%)	0.60^*
	HIV positive	2 (6%)	2 (12%)	4 (8%)

T-Test with Unequal Variance unless otherwise noted

^*

Fisher’s Exact Test