Table 5.

Cox proportional HRs and 95% CI for risk of all-cause mortality, CVD mortality and CVD events with increasing Mediterranean Diet Score (MDS) and Polygenic Risk Score in participants from the UK Biobank

	Overall (n=77 004)				Males (n=34 984)				Females (n=42 020)
	No of events	HR	95% CI	P value	No of events	HR	95% CI	P value	No of events	HR	95% CI	P value
All-cause mortality	2409				1416				993
MDS		0.95	(0.91 to 0.98)	0.005		0.93	(0.88 to 0.98)	0.004		0.97	(0.91 to 1.03)	0.33
Polygenic Risk Score		1.00	(0.96 to 1.04)	0.91		1.02	(0.97 to 1.07)	0.51		0.98	(0.92 to 1.05)	0.58
CVD mortality	364				263				101
MDS		0.97	(0.88 to 1.08)	0.60		0.94	(0.84 to 1.06)	0.32		1.07	(0.88 to 1.29)	0.49
Polygenic Risk Score		1.08	(0.98 to 1.20)	0.12		1.10	(0.98 to 1.25)	0.11		1.03	(0.85 to 1.25)	0.79
Myocardial infarction	1141				822				319
MDS		0.95	(0.90 to 1.00)	0.06		0.94	(0.88 to 1.00)	0.049		0.97	(0.88 to 1.08)	0.64
Polygenic Risk Score		1.33	(1.25 to 1.41)	<0.001		1.40	(1.31 to 1.50)	<0.001		1.16	(1.04 to 1.29)	0.008
Stroke	748				447				301
MDS		0.93	(0.87 to 1.00)	0.037		0.93	(0.85 to 1.01)	0.10		0.93	(0.83 to 1.04)	0.21
Polygenic Risk Score		1.02	(0.95 to 1.09)	0.67		0.97	(0.89 to 1.07)	0.57		1.08	(0.96 to 1.21)	0.19

Models were adjusted for age (continuous), sex (when not used to stratify), deprivation (categorical), smoking status (categorical), physical activity (continuous), medication use (binary), family history of CVD (binary), energy intake (continuous) and the first eight principal components of ancestry and genotyping batch. All models include main effects of diet quality and polygenic risk score but not interaction terms.

CVD, cardiovascular disease.