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. Author manuscript; available in PMC: 2022 Apr 2.
Published in final edited form as: Circ Res. 2021 Apr 1;128(7):887–907. doi: 10.1161/CIRCRESAHA.121.318064

Figure 2: Kidney precursors and their contribution to nephrovascular development.

Figure 2:

Schematic containing the four main progenitors that give rise to the whole kidney. The early metanephric mesenchyme is subdivided into condensed (Six2+ precursors, darker area) and loose (Foxd1+ and Endothelial precursors, lighter area) compartments. Highlighted in yellow are epithelial cells/structures that transiently express renin during early embryonic kidney development but do not originate from the same renin precursor that gives rise to mural cells of the vasculature. EC, endothelial cells; HSC, hematopoietic stem cell; SMC, smooth muscle cell. (Illustration credit: Ben Smith)