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. Author manuscript; available in PMC: 2022 Apr 2.
Published in final edited form as: Circ Res. 2021 Apr 1;128(7):887–907. doi: 10.1161/CIRCRESAHA.121.318064

Figure 8: Changes in renin cell fate result in disease.

Figure 8:

Conditional deletion (cKO) of crucial genes within renin cells, and genetic or pharmacological inhibition of the renin angiotensin system (RAS) result in cell fate changes ultimately leading to renal and systemic pathology. β-Rc, β-adrenergic receptor; Gsα, G protein α subunit; RBP-J, recombination signal binding protein for immunoglobulin Kappa J; CBF1, human homolog of RBP-J; Cx40, connexin 40; VHL, Von Hippel–Lindau gene; Ctcf, CCCTC-binding factor; Itgb1, integrin beta 1; Med1, Mediator complex subunit 1.