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. 2020 Aug 8;113(4):443–452. doi: 10.1093/jnci/djaa113

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Figure 4. — Prognostic impact of circulating tumor cells (CTCs) based on trajectory patterns during chemotherapy. A) Progression-free survival (PFS) and B) overall survival (OS) based on CTC trajectory (tCTC) in patients enrolled in the Cancer and Leukemia Group B 40502 trial. C) PFS and D) OS based on tCTC in patients in the Bidard et al. pooled analysis (European Pooled Analysis of individual CTC). Log-rank test was performed to compare survival curves. A 2-sided P less than .05 was considered significant.