FIGURE 2.

Estimates of cumulative risk of developing CRC from age 40 to 75 y defined by HLS [HLS1 (A) and HLS2 (B)] and PRS among all cohort members in the UK Biobank. Cumulative risk was adjusted for age at enrollment, sex, education, Townsend deprivation index, bowel screening, family history, top 5 principal components for ancestry, genotyping batch, and birth cohort. To estimate the RERI, the healthiest HLS and the lowest genetic risk (low PRS) groups were used as the reference. CRC, colorectal cancer; HLS, healthy lifestyle score; PRS, polygenic risk score; RERI, relative excess risk due to interaction.