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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Toxicol Sci. 2020 Oct 1;177(2):377–391. doi: 10.1093/toxsci/kfaa117

Table 2.

Model Parameters Describing Human Respiratory Tract Anatomy

Parameter Symbol Value Source
Tissue surface areas (cm2)
 Dorsal respiratory SADR 10.1 a, b, c
 Anterior dorsal olfactory SADO1 13.2 a, b, c
 Posterior dorsal olfactory SADO2 0.001 a, b, d
 Anterior ventral respiratory SAVR1 42.1 a, b, c
 Posterior ventral respiratory SAVR2 72.3 a, b, c
 Pharynx and larynx SAPL 192.3 a, b, c
 Conducting airways SACA 2000 a
 Pulmonary region SAPU 540 000 a
Mucus thickness (cm) WMUCUS 0.001 a, b, c
Tissue thicknesses (cm)
 Dorsal respiratory WTDR 0.005 a, b, c
 Dorsal olfactory (anterior and posterior) WTDO 0.004 a, b, c
 Ventral respiratory (anterior and posterior) WTVR 0.005 a, b, c
 Pharynx and larynx WTPL 0.0045 a, c, e
 Conducting airways WTCA 0.0045 a
 Pulmonary region WTPU 0.001 a
Submucosa thicknesses (cm)
 Dorsal respiratory WXDR 0.002 a, b, c
 Dorsal olfactory (anterior and posterior) WXDO 0.002 a, b, c
 Ventral respiratory (anterior and posterior) WXVR 0.002 a, b, c
 Pharynx and larynx WXPL 0.002 a, b, c
 Conducting airways WXCA 0.002 a
Lumen volumes (cm3)
 Dorsal respiratory VLDR 0.74 a, b, c
 Anterior dorsal olfactory VLDO1 0.56 a, b, c
 Posterior dorsal olfactory VLDO2 0.001 a, c, d
 Anterior ventral respiratory VLVR1 3.5 a, b, c
 Posterior ventral respiratory VLVR2 5.16 a, b, c
 Pharynx and larynx VLPL 37.5 a, b, c
 Conducting airways VLCA 95.7 a
a

Campbell et al. (2014), source code file “human.m.”

c

Additional (original) sources are cited by Campbell et al. (2014).

d

This value is set to a relatively small value because the posterior dorsal olfactory region does not exist in humans.

e

Value in Campbell et al. (2014) source code disagrees (substantially) with value in Campbell et al. (2014) manuscript.