Table 3.
Naphthalene-specific Biochemical Model Parameters for Humans
| Parameter | Symbol | Value | Source |
|---|---|---|---|
| Partition coefficients | |||
| Blood:air | HBA | 571 | a, b, c |
| Tissue:blood | HTB | 3.5 | a, b, c |
| Liver:blood | HLB | 1.6 | a, b, c |
| Fat:blood | HFB | 49 | a, b, c |
| Poorly perfused tissue:blood | HPPB | 3.5 | a, b, c |
| Richly perfused tissue:blood | HRPB | 2.12 | a, c, d |
| Lung:blood | HLUB | 1.71 | a |
| Air-phase mass transfer coefficients (cm/min) | |||
| Dorsal respiratory | KGDR | 197 | a, b, c |
| Anterior dorsal olfactory | KGDO1 | 1368 | a, b, c |
| Posterior dorsal olfactory | KGDO2 | 0.01 | a, c, e |
| Anterior ventral respiratory | KGVR1 | 158 | a, b, c |
| Posterior ventral respiratory | KGVR2 | 194 | a, b, c |
| Pharynx and larynx | KGPL | 5711 | a, b, c |
| Conducting airways | KGCA | 180 | a, b, c |
| Diffusivity in water (cm2/min) | DIFU | 0.00045 | a, b, c |
| Maximum metabolic rate (nmol/min/ml, to be multiplied by tissue volume) | |||
| Liver | VmaxLI | 100.8 | a, b, c |
| Lung | VmaxLU | 0.27 | a, b, c |
| Dorsal respiratory and olfactory | VmaxO | 6.76 | a, c, d |
| Ventral respiratory | VmaxV | 1.68 | a, c, d |
| Metabolic affinity constant (nmol/ml) | |||
| Liver | KmLI | 25.0 | a, b, c |
| Lung | KmLU | 82.0 | a, b, c |
| Dorsal respiratory and olfactory | KmO | 70.0 | a, b, c |
| Ventral respiratory | KmV | 11.5 | a, c, d |
Campbell et al. (2014), source code file “human.m.”
Campbell et al. (2014), Table 1, 2, or 3.
Additional (original) sources are cited by Campbell et al. (2014).
Value in Campbell et al. (2014) source code disagrees (substantially) with value in Campbell et al. (2014) manuscript.
This value is set to a relatively small value because the posterior dorsal olfactory region does not exist in humans.