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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Toxicol Sci. 2020 Oct 1;177(2):377–391. doi: 10.1093/toxsci/kfaa117

Table 3.

Naphthalene-specific Biochemical Model Parameters for Humans

Parameter Symbol Value Source
Partition coefficients
 Blood:air HBA 571 a, b, c
 Tissue:blood HTB 3.5 a, b, c
 Liver:blood HLB 1.6 a, b, c
 Fat:blood HFB 49 a, b, c
 Poorly perfused tissue:blood HPPB 3.5 a, b, c
 Richly perfused tissue:blood HRPB 2.12 a, c, d
 Lung:blood HLUB 1.71 a
Air-phase mass transfer coefficients (cm/min)
 Dorsal respiratory KGDR 197 a, b, c
 Anterior dorsal olfactory KGDO1 1368 a, b, c
 Posterior dorsal olfactory KGDO2 0.01 a, c, e
 Anterior ventral respiratory KGVR1 158 a, b, c
 Posterior ventral respiratory KGVR2 194 a, b, c
 Pharynx and larynx KGPL 5711 a, b, c
 Conducting airways KGCA 180 a, b, c
 Diffusivity in water (cm2/min) DIFU 0.00045 a, b, c
Maximum metabolic rate (nmol/min/ml, to be multiplied by tissue volume)
 Liver VmaxLI 100.8 a, b, c
 Lung VmaxLU 0.27 a, b, c
 Dorsal respiratory and olfactory VmaxO 6.76 a, c, d
 Ventral respiratory VmaxV 1.68 a, c, d
Metabolic affinity constant (nmol/ml)
 Liver KmLI 25.0 a, b, c
 Lung KmLU 82.0 a, b, c
 Dorsal respiratory and olfactory KmO 70.0 a, b, c
 Ventral respiratory KmV 11.5 a, c, d
a

Campbell et al. (2014), source code file “human.m.”

c

Additional (original) sources are cited by Campbell et al. (2014).

d

Value in Campbell et al. (2014) source code disagrees (substantially) with value in Campbell et al. (2014) manuscript.

e

This value is set to a relatively small value because the posterior dorsal olfactory region does not exist in humans.