Table 4.
Skin-related Parameters for Two-Compartment (2C) and Partial Differential Equation (PDE) Skin Models for Humans
| Parameter | Symbols | Value | Source |
|---|---|---|---|
| Tissue dimensions | |||
| SC thickness (cm) | TSC, TSC | 0.003 | McCarley and Bunge (2001) |
| VE thickness (cm) | TVE, TVE | 0.0075 | McCarley and Bunge (2001) |
| Partition coefficients | |||
| SC:VE | HSC:VE, HSCVE | 1.98 | McCarley and Bunge (2001) |
| SC:JP-8 | HSC:JP8, HSCJP8 | Varies | Calibrated |
| VE:JP-8a | HVE:JP8, HVEJP8 | Varies | Calculated |
| VE:blood | HVE:blood, HVEB | 2.73 | McCarley and Bunge (2001) |
| Diffusivity constants (cm2/min) | |||
| Naphthalene through SC | DSC, DSC | Varies | Calibrated |
| Naphthalene through VEa | DVE, DVE | 0.00482 | McCarley and Bunge (2001) |
| Exposure parameters | |||
| Intravenous dose rate (nmol/min)b | RIV | Varies | Calibrated |
| Surface area of exposed skin (cm2) | E, AEXP | 20 | Kim et al. (2006) |
| JP-8 volume in exposure well (ml) | VWELL | 1.0 | Kim et al. (2006) |
| Exposure time (min) | texp, exp_time | Varies | Kim et al. (2006) |
| Naphthalene conc. in JP-8 (g/ml) | CNJP8 | 0.003 | Kim et al. (2006) |
a
These parameters were used in the 2C model but not in the PDE model.
b
Intravenous dose rate is used to account for “background” blood concentrations of naphthalene observed in the subjects from the Kim et al. (2006) study prior to exposure.