Table 1.
Baseline characteristics and predictors of poor outcomes at day 30 for 367 patients with HIV-associated talaromycosis included in the training dataset.
| Good outcomes n = 261 | Poor outcomes n = 106 | Odds ratio | 2.5% (lower) | 97.5% (upper) | |
|---|---|---|---|---|---|
| Sex (male) | 0.81 | 0.88 | 1.12 | 0.59 | 2.17 |
| IVDU (yes) | 0.64 | 0.81 | 2.01 | 1.14 | 3.56 |
| Fever (>38°C) | 0.34 | 0.27 | 0.56 | 0.32 | 0.98 |
| Pulse (beats/minute) | 99.39 | 104.06 | 1.00 | 0.98 | 1.02 |
| Respiratory rate (breaths/minute) | 25.41 | 31.44 | 1.12 | 1.07 | 1.17 |
| Skin lesions (yes) | 0.73 | 0.64 | 0.78 | 0.46 | 1.32 |
| Absolute lymphocyte count (cells/μl) | 0.49 | 1.02 | 1.62 | 1.11 | 2.44 |
| Hemoglobin (g/dl) | 7.73 | 7.87 | 0.98 | 0.88 | 1.10 |
| Platelets (103/μl) | 127.76 | 86.07 | 1.00 | 0.99 | 1.00 |
| Creatinine (10 μmol/l) | 9.02 | 15.90 | 1.08 | 1.04 | 1.14 |
| AST (10 units/l) | 15.19 | 26.13 | 1.02 | 1.01 | 1.04 |
| Lower respiratory infection (yes) | 0.28 | 0.43 | 1.67 | 1.01 | 2.75 |
| CNS infection (yes) | 0.02 | 0.23 | 2.66 | 1.30 | 5.48 |
| Fungemia (yes) | 0.93 | 0.96 | 1.23 | 0.55 | 2.80 |
Note: Summary statistics are presented as count (percentage) of positive value for categorical variables and mean for continuous variables. Odds ratios and upper and lower bounds for 95% credible intervals (CI) are estimated from the Bayesian multivariate logistic regression model, and were therefore adjusted by the model covariates. AST: aspartate aminotransferase, CNS: central nervous system, IVDU: intravenous drug use.