TABLE 3.
Systolic and diastolic blood pressure at baseline or 2 mo into the study and percentage change from baseline or from 2 mo at 12 and 24 mo1
| n | Baseline | 2 mo | Δ at 12 mo, % | Δ at 24 mo, % | P difference2 | P trend2 | P ANCOVA3 | |
|---|---|---|---|---|---|---|---|---|
| Systolic blood pressure, mm Hg | ||||||||
| Soy | ||||||||
| Not on hypertension medication4 | ||||||||
| 26 | 133.7 (126.1, 141.3) | –3.4 (–7.5, 0.8) | –2.7 (–7.0, 1.5) | 0.078 | 0.109 | 0.693 | ||
| 21 | 130.5 (124.3, 136.8) | –1.6 (–4.6, 1.4)5 | –0.6 (–5.4, 4.1)5 | 0.7635 | 0.8295 | 0.8746 | ||
| On hypertension medication6 | ||||||||
| 18 | 135.6 (126.6, 144.9) | –1.9 (–8.2, 4.5) | –1.8 (–8.7, 5.1) | 0.564 | 0.369 | 0.065 | ||
| Placebo | ||||||||
| Not on hypertension medication4 | ||||||||
| 16 | 131.8 (123.4, 140.1) | –3.2 (–9.4, 3.0) | –2.5 (–9.4, 4.4) | 0.269 | 0.296 | |||
| 15 | 128.3 (119.0, 137.6) | 0.4 (–5.9, 6.7)5 | 0.4 (–5.8, 6.6)5 | 0.9675 | 0.8595 | |||
| On hypertension medication6 | ||||||||
| 20 | 138.6 (129.8, 147.4) | –4.1 (–8.5, 0.3) | –7.3 (–12.6, –2.1) | 0.012 | 0.012 | |||
| Diastolic blood pressure, mm Hg | ||||||||
| Soy | ||||||||
| Not on hypertension medication4 | ||||||||
| 26 | 79.6 (75.9, 83.3) | –3.5 (–6.6, 2.5) | –1.4 (–6.1, 3.3) | 0.129 | 0.357 | 0.748 | ||
| 24 | 78.8 (75.5, 82.2) | –2.8 (–5.8, 0.3)5 | –0.8 (–4.6, 3.1)5 | 0.1925 | 0.5335 | 0.4335 | ||
| On hypertension medication6 | ||||||||
| 18 | 81.6 (76.0, 87.1) | –0.8 (–7.3, 5.8) | –6.2 (–19.0, 6.7) | 0.831 | 0.704 | 0.923 | ||
| Placebo | ||||||||
| Not on hypertension medication4 | ||||||||
| 16 | 79.1 (75.0, 83.3) | –3.7 (–8.9, 1.4) | –3.9 (–10.0, 2.2) | 0.165 | 0.159 | |||
| 15 | 76.9 (73.2, 80.5) | –1.4 (–8.3, 5.4)5 | –1.8 (–8.7, 5.1)5 | 0.7435 | 0.5205 | |||
| On hypertension medication6 | ||||||||
| 20 | 79.4 (74.2, 84.5) | –3.6 (–10.9, 3.7) | –5.2 (–10.6, 0.3) | 0.138 | 0.063 | |||
Values are means (95% CIs). Only subjects with complete data on blood pressure at baseline or 2 mo and at 12 and 24 mo and age and height at baseline are included in this analysis.
One-way repeated-measures ANOVA of change over time.
ANCOVA for difference in percentage change from baseline between the 2 treatments at 24 mo, with age, height, and weight at baseline as covariates.
Only subjects not on antihypertensive medication (self-reported) at any time during the study and with complete data on blood pressure at baseline, 12 mo, and 24 mo and age and height at baseline are included.
The 12- and 24-mo data were compared with those of the first study visit occurring 2 mo after baseline.
These are subjects who self-reported to be on antihypertensive medication at any time during the study and for whom there were complete data on blood pressure at baseline and 24 mo and age and height at baseline.