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. Author manuscript; available in PMC: 2021 Apr 6.
Published in final edited form as: Nature. 2020 Aug 19;586(7829):452–456. doi: 10.1038/s41586-020-2636-7

Figure 2: Crystal structure of substrate-bound FBXL17 reveals specificity determinants of DQC.

Figure 2:

a. Side view of the 3.2 Å X-ray structure of a complex between SKP1 (gray), FBXL17 (orange), and the BTB domain of KEAP1F64A (residues 48-180; blue). b. Top view of the SKP1-FBXL17-BTB complex showing how FBXL17 encircles the BTB domain through its LRRs and the C-terminal helix (CTH). c. Side view of the SKP1-FBXL17-BTB complex. d. The CTH binds a conserved area of the BTB domains (blue: high conservation; red: low conservation). e. The CTH crosses the dimerization interface of the BTB domain in a position typically occupied by another subunit in the BTB dimer (green).