Figure 6.

Quercetin (Que) ameliorates ER stress in human cardiomyocytes under conditions of hypoxia/reoxygenation (H/R): (a) calcium released from cardiomyocytes, as observed by laser confocal microscopy; (b–d) levels of the PERK, CHOP, and caspase-12 mRNAs determined by qPCR; (e–g) protein levels of p-PERK, CHOP, caspase-12, and GAPDH determined by western blotting; (h) mRNA and protein levels of TMBIM6 determined by qPCR and western blotting, respectively. ^∗p < 0.05. Con: control; SIRT1 siRNA: SIRT1 short interfering RNA.