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Optimized compounds designed to accommodate the p2 pocket of Mcl-1 and Bfl-1with terminal R2 tert-butyl moiety.
 | ||||
|---|---|---|---|---|
| Compound | R1 | R2 | Mcl-1 Ki (μM) | Bfl-1 Ki (μM) |
| 23 |  |
 |
0.073 ± 0.02 | 0.084 ± 0.04 |
| 24 |  |
 |
0.094 ± 0.01 | 0.10 ± 0.02 |
| 25 |  |
 |
0.29 ± 0.01 | 0.25 ± 0.05 |
| 26 |  |
 |
0.074 ± 0.01 | 0.10 ± 0.04 |
| 27 |  |
 |
0.95 ± 0.08 | 1.1 ± 0.4 |
