Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding selectivity profiles of select compounds to anti-apoptotic proteins
| Compound | Mcl-1 Ki (μM) | Bfl-1 Ki (μM) | Bcl-2 Ki (μM) | Bcl-xL Ki (μM) |
|---|---|---|---|---|
| 1 | 1.5 ± 0.3 | 1.6 ± 0.2 | >25 | >25 |
| 15 | 0.22 ± 0.03 | 0.57 ± 0.1 | 5.6 ± 0.7 | 5.2 ± 1.1 |
| 20 | 0.57 ± 0.1 | 0.76 ± 0.1 | 11.7 ± 3.1 | 6.6 ± 1.1 |
| 22 | 0.77 ± 0.2 | 0.90 ± 0.2 | >25 | >25 |
| 23 | 0.073 ± 0.02 | 0.084 ± 0.04 | 1.2 ± 0.4 | 3.5 ± 0.5 |
| 24 | 0.094 ± 0.01 | 0.10 ± 0.02 | >25 | >25 |
| 26 | 0.074 ± 0.01 | 0.10 ± 0.04 | 1.2 ± 0.5 | 6.7 ± 1.6 |
| 27 | 0.95 ± 0.08 | 1.1 ± 0.4 | 16.1 ± 0.9 | >25 |
