Table 1.
The parameters of differential metabolites selected from six cross-comparisons
| Metabolites | VIP | P value | P adjusted | Log2 (fold change) | AUC |
|---|---|---|---|---|---|
| IFG vs. NI | |||||
| C6DC | 2.676 | 2.10E-11 | 1.22E-09 | 3.282 | 0.950 |
| C14 | 2.308 | 4.79E-10 | 6.94E-09 | 1.874 | 0.917 |
| C12 | 2.246 | 1.43E-10 | 2.76E-09 | 4.086 | 0.930 |
| C14-OH | 2.166 | 8.61E-11 | 2.50E-09 | 2.283 | 0.930 |
| C14:1 | 1.931 | 2.70E-08 | 3.14E-07 | 2.077 | 0.872 |
| Leu | 1.786 | 1.25E-05 | 7.23E-05 | –0.955 | 0.793 |
| C16 | 1.750 | 1.69E-06 | 1.40E-05 | 1.129 | 0.821 |
| C14:2 | 1.702 | 5.15E-07 | 4.98E-06 | 1.507 | 0.837 |
| Cit | 1.690 | 2.49E-06 | 1.81E-05 | –1.236 | 0.816 |
| SD vs. IFG | |||||
| Cit | 2.629 | 9.62E-08 | 5.58E-06 | 1.811 | 0.960 |
| C16:1-OH | 2.085 | 2.33E-05 | 6.76E-04 | –1.074 | 0.863 |
| Try | 1.994 | 1.00E-04 | 1.45E-03 | 0.800 | 0.836 |
| C8 | 1.820 | 4.30E-05 | 8.32E-04 | 2.055 | 0.852 |
| Asn | 1.789 | 5.45E-04 | 6.32E-03 | 0.695 | 0.799 |
| Leu | 1.575 | 2.32E-03 | 1.92E-02 | 0.998 | 0.763 |
| DMVC vs. SD | |||||
| C16 | 2.155 | 9.56E-08 | 5.54E-06 | –2.976 | 0.944 |
| Asn | 1.866 | 7.61E-07 | 2.21E-05 | –1.120 | 0.911 |
| C14:2 | 1.766 | 8.84E-04 | 4.66E-03 | –0.899 | 0.777 |
| C8 | 1.634 | 3.97E-04 | 2.56E-03 | –1.387 | 0.794 |
| C14 | 1.607 | 2.57E-04 | 1.86E-03 | –1.499 | 0.803 |
| C6DC | 1.586 | 1.70E-04 | 1.65E-03 | –0.856 | 0.813 |
| Gln | 1.558 | 1.03E-05 | 1.99E-04 | –1.034 | 0.867 |
| DPVD vs. SD | |||||
| C6DC | 2.403 | 7.56E-06 | 4.38E-04 | –4.332 | 1.000 |
| Orn | 2.330 | 5.15E-03 | 3.32E-02 | 1.550 | 0.813 |
| Met | 2.020 | 1.16E-03 | 1.81E-02 | –1.386 | 0.864 |
| C14:2 | 1.945 | 3.25E-04 | 9.42E-03 | –2.070 | 0.902 |
| C14DC | 1.857 | 4.13E-03 | 2.99E-02 | –1.118 | 0.818 |
| Try | 1.736 | 1.25E-03 | 1.81E-02 | –1.172 | 0.861 |
| C18-OH | 1.575 | 2.94E-03 | 2.45E-02 | –1.640 | 0.828 |
| DPVD & DMVC vs. SD | |||||
| Gln | 1.881 | 1.25E-09 | 3.62E-08 | –3.783 | 1.000 |
| C6DC | 1.852 | 1.24E-09 | 3.62E-08 | –2.965 | 1.000 |
| Hcy | 1.677 | 5.24E-08 | 7.60E-07 | –5.112 | 0.948 |
| Phe | 1.618 | 8.28E-09 | 1.60E-07 | –2.934 | 0.974 |
| Tyr | 1.590 | 8.11E-08 | 8.53E-07 | –1.951 | 0.942 |
| C14:2 | 1.506 | 6.16E-07 | 3.97E-06 | –2.039 | 0.910 |
| DPVD & DMVC vs. DMVC | |||||
| Hcy | 2.008 | 6.05E-12 | 2.10E-10 | 0.384 | 0.972 |
| Cys | 1.898 | 1.09E-11 | 2.10E-10 | 0.236 | 0.966 |
| C16 | 1.720 | 1.05E-11 | 2.10E-10 | –0.281 | 0.966 |
| C22 | 1.595 | 9.99E-11 | 1.16E-09 | 0.147 | 0.941 |
| C18 | 1.556 | 1.79E-10 | 1.55E-09 | 0.677 | 0.937 |
| Phe | 1.521 | 1.87E-10 | 1.55E-09 | 0.432 | 0.937 |
VIP, variable importance in projection; AUC, area under curve; IFG, impaired fasting glucose; NI, normal individual; SD, simple diabetes; DMVC, diabetic microvascular complication; DPVD, diabetic peripheral vascular disease.