Fig. 2. Epigenetic annotation for the region surrounding rs4947941 and rs7785013. The topologically associating domain (TAD) data in the GM12878 cell line were downloaded from the Gene Expression Omnibus (GEO) data, GSE63525. TAD-like domains were identified using promoter capture Hi-C in human pancreatic islets. Chromatin interaction data in multiple cell lines were downloaded from the 4DGenome Database. Active histone modifications, including H3k4me1, H3k4me3, and H3k27ac, in pancreatic islets were obtained from the Roadmap Project using the WashU EpiGenome Browser. EGFR, epidermal growth factor receptor.